The exact mechanisms of action of policosanol are not completely clear, however, it is thought that policosanol exerts its effects by:
- Increasing the breakdown of LDL cholesterol by the liver.
- Blocking activity of HMG-CoA reductase, an enzyme involved in the production of cholesterol.
- Reducing the grouping together of platelets, which helps prevents clotting.
- Decreasing activity of serum cholesteryl ester transfer protein (CETP), which increases HDL and decreases LDL levels.
Long-term studies (DB-RCTs), some up to 3 years and 1 including 2252 older patients, have shown policosanol to be safe.
J&B Policosanol is made with the highest quality ingredients under strict Therapeutical Goods Administration (TGA) guidelines.